Viewpoints:

Dispatches from the Frontlines of Research - edited by John W. Nelson

Mordecai P. Blaustein, Shawn W. Robinson, Stephen S. Gottlieb, C. William Balke, and John M. Hamlyn

Sex, Digitalis, and the Sodium Pump
Mol. Interv. 2003 3: 68-72. [Summary] [Full Text] [PDF]  

Jeremy Veenstra-VanderWeele and Edwin H. Cook, Jr.

Knockout Mouse Points to Second Form of Tryptophan Hydroxylase
Mol. Interv. 2003 3: 72-75. [Summary] [Full Text] [PDF]  

Ronald L. Wange

The Missing Link(er): A Return to Symmetry in Antigen Receptor Signaling?
Mol. Interv. 2003 3: 75-78. [Summary] [Full Text] [PDF]  

R E V I E W S:

Holger Nilsson and Christian Aalkjær

Vasomotion: Mechanisms and Physiological Importance
Mol. Interv. 2003 3: 79-89. [Summary] [Full Text] [PDF]  

That smooth muscles dilate and contract rhythmically has been known for a long time and the phenomenon has been studied for nearly as long. However, the causes and effects of smooth muscle oscillation (termed vasomotion) are far from clear. It is thought that vasomotion aids the delivery of oxygen to tissues surrounding capillary beds. On the other hand, unregulated vasomotion might participate in the development and maintenance of pathophysiological states. Nilsson and Aalkjar review what is known about vasomotion and its consequences.

William M. Pardridge

BLOOD-BRAIN BARRIER DRUG TARGETING: THE FUTURE OF BRAIN DRUG DEVELOPMENT
Mol. Interv. 2003 3: 90-105. [Summary] [Full Text] [PDF]  

As human longevity increases, the likelihood of the onset of diseases of the brain (and other organs) also increases. Clinical therapeutics offer useful long-term treatments, if not cures, if drugs can be delivered appropriately and effectively. Unfortunately, research in drug transport to the brain has not advanced very far. Through better characterization of the transport systems utilized within the blood-brain barrier, a greater understanding of how to exploit these systems will lead to effective treatments for brain disorders. Pardridge reviews the functions of the various known transport systems in the brain and discusses how the development of BBB drug-targeting programs in pharmaceutical and academic settings may lead to more efficacious treatments.

D E P A R T M E N T S:

Speaking of Pharmacology:

Harry B. Smith

Of Timelines and Bylines
Mol. Interv. 2003 3: 49. [Full Text] [PDF]  

Reflections:

Science in the cultural context

David A. Kirby

Science Advisors, Representation, and Hollywood Films
Mol. Interv. 2003 3: 54-60. [Full Text] [PDF]  

CrossTalk:

Interviews with people in the world of pharmacology

A Career, in Sequences
Mol. Interv. 2003 3: 62-66. [Summary] [Full Text] [PDF]  

Beyond the Bench:

Representations of pharmacology and science in the media

Christie Carrico

Drug Highs, Drug Lows
Mol. Interv. 2003 3: 106-107. [Full Text] [PDF]  

Net Results:

Sites of interest on the World Wide Web

Sites of interest on the World Wide Web—edited by David Siderovski
Mol. Interv. 2003 3: 112. [Full Text] [PDF]  

Outliers:

Cartoon

Mol. Interv. 2003 3: 107. [Full Text] [PDF]  

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