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Current Issue: April 1, 2008; 8 (2) [Table of Contents]

Keith J. Miller and Anthony V. Azzara

An Old Dog Learns a New Trick: Regulation of Peripheral Glucose Homeostasis by the Serotonin (5-HT)_2C Receptor
MI 2008 8: 73 10.1124/mi.8.2.4 [Summary] [Full Text] [PDF]  
Published April 1, 2008

Josephine M. Egan and Robert F. Margolskee

Taste Cells of the Gut and Gastrointestinal Chemosensation
MI 2008 8: 78 10.1124/mi.8.2.5 [Summary] [Full Text] [PDF]  
Published April 1, 2008

Past Issues:

Kathrin Muegge, Sichuan Xi, and Theresa Geiman

The See-saw of Differentiation: Tipping the Chromatin Balance
MI 2008 8: 15 10.1124/mi.8.1.4 [Summary] [Full Text] [PDF]  
Published February 1, 2008

Joanne Elliott

SOCS3 in Liver Regeneration and Hepatocarcinoma
MI 2008 8: 19 10.1124/mi.8.1.5 [Summary] [Full Text] [PDF]  
Published February 1, 2008

L. Keith Henry, Jens Meiler, and Randy D. Blakely

Bound to Be Different: Neurotransmitter Transporters Meet Their Bacterial Cousins
MI 2007 7: 306 10.1124/mi.7.6.4 [Summary] [Full Text] [PDF]  
Published December 1, 2007

Peter M. Blumberg

Lighting a Backfire to Quench the Blaze: A Combined Drug Approach Targeting the Vanilloid Receptor TRPV1
MI 2007 7: 310 10.1124/mi.7.6.5 [Summary] [Full Text] [PDF]  
Published December 1, 2007

Karl Peter Giese

Novel Insights into the Beneficial and Detrimental Actions of Cdk5
MI 2007 7: 246 10.1124/mi.7.5.5 [Summary] [Full Text] [PDF]  
Published October 1, 2007

Panagiotis A. Tsonis

Bridging Knowledge Gaps on the Long Road to Regeneration: Classical Models Meet Stem Cell Manipulation and Bioengineering
MI 2007 7: 249 10.1124/mi.7.5.6 [Summary] [Full Text] [PDF]  
Published October 1, 2007

Anthony M. Rush and Theodore R. Cummins

Painful Research: Identification of a Small-Molecule Inhibitor that Selectively Targets Na_v1.8 Sodium Channels
MI 2007 7: 192 10.1124/mi.7.4.4 [Summary] [Full Text] [PDF]  
Published August 1, 2007

Leo Timmers, Gerard Pasterkamp, and Dominique P.V. de Kleijn

Microsomal Prostaglandin E₂ Synthase: A Safer Target than Cyclooxygenases?
MI 2007 7: 195 10.1124/mi.7.4.5 [Summary] [Full Text] [PDF]  
Published August 1, 2007

Andrei Goga and Christopher Benz

Anti-Oncomir Suppression of Tumor Phenotypes
MI 2007 7: 199 10.1124/mi.7.4.6 [Summary] [Full Text] [PDF]  
Published August 1, 2007

Qiang Ma

Aryl Hydrocarbon Receptor Degradation-Promoting Factor (ADPF) and the Control of the Xenobiotic Response
MI 2007 7: 133 10.1124/mi.7.3.4 [Summary] [Full Text] [PDF]  
Published June 1, 2007

John K. Amory

Inhibiting Sperm Motility for Male Contraception: Will the Sperm Tail Be its "Achilles Heel"?
MI 2007 7: 68 10.1124/mi.7.2.5 [Summary] [Full Text] [PDF]  
Published April 1, 2007

Val J. Watts

Adenylyl Cyclase Isoforms as Novel Therapeutic Targets: An Exciting Example of Excitotoxicity Neuroprotection
MI 2007 7: 70 10.1124/mi.7.2.6 [Summary] [Full Text] [PDF]  
Published April 1, 2007

Mary Jeanne Kreek and K. Steven LaForge

Stress Responsivity, Addiction, and a Functional Variant of the Human Mu-Opioid Receptor Gene
MI 2007 7: 74 10.1124/mi.7.2.7 [Summary] [Full Text] [PDF]  
Published April 1, 2007

Wenqing Gao and James T. Dalton

Ockham’s Razor and Selective Androgen Receptor Modulators (SARMs): Are We Overlooking the Role of 5-Reductase?
MI 2007 7: 10 10.1124/mi.7.1.3 [Summary] [Full Text] [PDF]  
Published February 1, 2007

Mark Nichols

The Fight Against Tamoxifen Resistance in Breast Cancer Therapy: A New Target in the Battle?
MI 2007 7: 13 10.1124/mi.7.1.4 [Summary] [Full Text] [PDF]  
Published February 1, 2007

Swapnil Sonkusare, Mony Fraer, James D. Marsh, and Nancy J. Rusch

Disrupting Calcium Channel Expression To Lower Blood Pressure: New Targeting of a Well-Known Channel
MI 2006 6: 304 10.1124/mi.6.6.3 [Summary] [Full Text] [PDF]  
Published December 1, 2006

Daniel S. McGehee

Nicotinic and Opioid Receptor Interactions in Nicotine Addiction
MI 2006 6: 311 10.1124/mi.6.6.4 [Summary] [Full Text] [PDF]  
Published December 1, 2006

Neil Osheroff

Unraveling the Structure of the Variola Topoisomerase IB-DNA Complex: A Possible New Twist on Smallpox Therapy
MI 2006 6: 245 10.1124/mi.6.5.4 [Summary] [Full Text] [PDF]  
Published October 1, 2006

Molly J. Carlson and David E. Cummings

Prospects for an Anti-Ghrelin Vaccine to Treat Obesity
MI 2006 6: 249 10.1124/mi.6.5.5 [Summary] [Full Text] [PDF]  
Published October 1, 2006

Helen P. Carroll, Benjamin B.A. McNaull, and Massimo Gadina

Immunodeficiency Is A Tough Nut to CRAC: The Importance of Calcium Flux in T Cell Activation
MI 2006 6: 253 10.1124/mi.6.5.6 [Summary] [Full Text] [PDF]  
Published October 1, 2006

Paula H. Stern

The Calcineurin-NFAT Pathway and Bone: Intriguing New Findings
MI 2006 6: 193 10.1124/mi.6.4.4 [Summary] [Full Text] [PDF]  
Published August 1, 2006

Wolfgang Sadée and Laura Bohn

How Specific Are "Target-Specific" Drugs? Celecoxib as a Case in Point
MI 2006 6: 196 10.1124/mi.6.4.5 [Summary] [Full Text] [PDF]  
Published August 1, 2006

Izabela Podgorski and Bonnie F. Sloane

Loss of Caspase-8 in Tumor Cells: Mechanism to Overcome Integrin-Mediated Death?
MI 2006 6: 132 10.1124/mi.6.3.3 [Summary] [Full Text] [PDF]  
Published June 1, 2006

Thomas E. Willnow and Olav M. Andersen

Pin-pointing APP Processing
MI 2006 6: 137 10.1124/mi.6.3.4 [Summary] [Full Text] [PDF]  
Published June 1, 2006

Bianca Rocca

Targeting PGE₂ Receptor Subtypes Rather Than Cyclooxygenases: A Bridge Over Troubled Water?
MI 2006 6: 68 10.1124/mi.6.2.3 [Summary] [Full Text] [PDF]  
Published April 1, 2006

Sanjiv Shah and Gang Yu

sorLA: Sorting Out APP
MI 2006 6: 74 10.1124/mi.6.2.4 [Summary] [Full Text] [PDF]  
Published April 1, 2006

Ryan M. Fryer, Glenn A. Reinhart, and Timothy A. Esbenshade

Histamine in Cardiac Sympathetic Ganglia: A Novel Neurotransmitter?
MI 2006 6: 14 10.1124/mi.6.1.3 [Summary] [Full Text] [PDF]  
Published February 1, 2006

Tobias Schmid and Matthew R. Young

Lights on for Low Oxygen: A Noninvasive Mouse Model Useful for Sensing Oxygen Deficiency
MI 2006 6: 20 10.1124/mi.6.1.4 [Summary] [Full Text] [PDF]  
Published February 1, 2006

Robert J. Tomko Jr., Pallavi Bansal, and John S. Lazo

Airing Out an Antioxidant Role for the Tumor Suppressor p53
MI 2006 6: 23 10.1124/mi.6.1.5 [Summary] [Full Text] [PDF]  
Published February 1, 2006

Igor E. Brodsky and John S. Gunn

A Bacterial Sensory System that Activates Resistance to Innate Immune Defenses: Potential Targets for Antimicrobial Therapeutics
MI 2005 5: 335 10.1124/mi.5.6.4 [Summary] [Full Text] [PDF]  
Published December 1, 2005

Benjamin C. Lin and Thomas S. Scanlan

Few Things in Life are "Free": Cellular Uptake of Steroid Hormones by an Active Transport Mechanism
MI 2005 5: 338 10.1124/mi.5.6.5 [Summary] [Full Text] [PDF]  
Published December 1, 2005

Rafael Villalobos-Molina and Maximiliano Ibarra

Increased Expression and Function of Vascular _1D-Adrenoceptors May Mediate The Prohypertensive Effects Of Angiotensin II
MI 2005 5: 340 10.1124/mi.5.6.6 [Summary] [Full Text] [PDF]  
Published December 1, 2005

Carolyn A. Worby and Jack E. Dixon

Phosphoinositide Phosphatases: Emerging Roles As Voltage Sensors?
MI 2005 5: 274 10.1124/mi.5.5.5 [Summary] [Full Text] [PDF]  
Published October 1, 2005

Mark P. Mattson and Marc Gleichmann

The Neuronal Death Protein Par-4 Mediates Dopaminergic Synaptic Plasticity
MI 2005 5: 278 10.1124/mi.5.5.6 [Summary] [Full Text] [PDF]  
Published October 1, 2005

Ajay Goel, Christoph Gasche, and C. Richard Boland

Chemoprevention Goes Gourmet: Different Flavors of NO-Aspirin
MI 2005 5: 207 10.1124/mi.5.4.3 [Summary] [Full Text] [PDF]  
Published August 1, 2005

Marko Pesu, John O’Shea, Lothar Hennighausen, and Olli Silvennoinen

Identification of an Acquired Mutation in Jak2 Provides Molecular Insights into the Pathogenesis of Myeloproliferative Disorders
MI 2005 5: 211 10.1124/mi.5.4.4 [Summary] [Full Text] [PDF]  
Published August 1, 2005

Evan D. Kharasch, Kenneth E. Thummel, and Paul B. Watkins

CYP3A Probes Can Quantitatively Predict the In Vivo Kinetics of Other CYP3A Substrates and Can Accurately Assess CYP3A Induction and Inhibition
MI 2005 5: 151 10.1124/mi.5.3.3 [Summary] [Full Text] [PDF]  
Published June 1, 2005

Mark A. Simmons

Functional Selectivity, Ligand-Directed Trafficking, Conformation-Specific Agonism: What’s In A Name?
MI 2005 5: 154 10.1124/mi.5.3.4 [Summary] [Full Text] [PDF]  
Published June 1, 2005

Ahmed Hasbi, Brian F. O’Dowd, and Susan R. George

A G Protein–Coupled Receptor For Estrogen: The End Of The Search?
MI 2005 5: 158 10.1124/mi.5.3.5 [Summary] [Full Text] [PDF]  
Published June 1, 2005

Luigia Santella

NAADP: A New Second Messenger Comes of Age
MI 2005 5: 70 10.1124/mi.5.2.3 [Summary] [Full Text] [PDF]  
Published April 1, 2005

Antony Galione and Ole H. Petersen

The NAADP Receptor: New Receptors or New Regulation?
MI 2005 5: 73 10.1124/mi.5.2.4 [Summary] [Full Text] [PDF]  
Published April 1, 2005

Leslie Z. Benet

There Are No Useful CYP3A Probes that Quantitatively Predict the In Vivo Kinetics of Other CYP3A Substrates and No Expectation that One Will Be Found
MI 2005 5: 79 10.1124/mi.5.2.5 [Summary] [Full Text] [PDF]  
Published April 1, 2005

Phillip M. Gerk and Mary Vore

The Ileocyte Basolateral Organic Solute Transporter (OST–OSTß) Complex: Finding The Missing Link in Enterohepatic Circulation
MI 2005 5: 8 10.1124/mi.5.1.3 [Summary] [Full Text] [PDF]  
Published February 1, 2005

Hong D. Xiao and Kenneth E. Bernstein

Mast Cells: The Missing Source of Cardiac Renin?
MI 2005 5: 11 10.1124/mi.5.1.4 [Summary] [Full Text] [PDF]  
Published February 1, 2005

Theodore D. Chung and William C. Broaddus

Molecular Targeting in Radiotherapy: Epidermal Growth Factor Receptor
MI 2005 5: 15 10.1124/mi.5.1.5 [Summary] [Full Text] [PDF]  
Published February 1, 2005

Dzung H. Nguyen and Dennis D. Taub

Targeting Lipids to Prevent HIV Infection
MI 2004 4: 318 10.1124/mi4.6.3 [Summary] [Full Text] [PDF]  
Published December 1, 2004

Chris Hague, Randy A. Hall, and Kenneth P. Minneman

Olfactory Receptor Localization and Function: An Emerging Role for GPCR Heterodimerization
MI 2004 4: 321 10.1124/mi.4.6.4 [Summary] [Full Text] [PDF]  
Published December 1, 2004

Gergely Szakács and Michael M. Gottesman

Comparing Solid Tumors with Cell Lines: Implications for Identifying Drug Resistance Genes in Cancer
MI 2004 4: 323 10.1124/mi.4.6.5 [Summary] [Full Text] [PDF]  
Published December 1, 2004

Jin Mo Chung

The Role of Reactive Oxygen Species (ROS) in Persistent Pain
MI 2004 4: 248 10.1124/mi.4.5.3 [Summary] [Full Text] [PDF]  
Published October 1, 2004

Sándor Damjanovich, Rezsó Gáspár, and György Panyi

An Alternative to Conventional Immunosuppression: Small-Molecule Inhibitors of K_v1.3 Channels
MI 2004 4: 250 10.1124/mi.4.5.4 [Summary] [Full Text] [PDF]  
Published October 1, 2004

Tomoshige Kino and George P. Chrousos

Combating Atherosclerosis With LXR And PPAR Agonists: Is Rational Multitargeted Polypharmacy the Future of Therapeutics in Complex Diseases?
MI 2004 4: 254 10.1124/mi.4.5.5 [Summary] [Full Text] [PDF]  
Published October 1, 2004

Helge Eilers and Mark A. Schumacher

Opioid-induced Respiratory Depression: Are 5-HT_4a Receptor Agonists the Cure?
MI 2004 4: 197 10.1124/mi.4.4.3 [Summary] [Full Text] [PDF]  
Published August 1, 2004

Oonagh T. Lynch and Massimo Gadina

Ubiquitination for Activation: New Directions in the NF-B Roadmap
MI 2004 4: 144 10.112/4.3.3 [Summary] [Full Text] [PDF]  
Published June 1, 2004

Christopher D. Heger and Ruth N. Collins

Platelet Activation and "Crossover Appeal": Rab and Rho Families United by Common Links to Serotonin
MI 2004 4: 79 10.1124/mi.4.2.3 [Summary] [Full Text] [PDF]  
Published April 1, 2004

Panagiotis A. Tsonis

Stem Cells from Differentiated Cells
MI 2004 4: 81 10.1124/mi.4.2.4 [Summary] [Full Text] [PDF]  
Published April 1, 2004

Sungwoo Kim, Gus R. Rosania, and Young-Tae Chang

Dedifferentiation? What’s next?
MI 2004 4: 83 10.1124/mi.4.2.5 [Summary] [Full Text] [PDF]  
Published April 1, 2004

Edward Perez-Reyes

Paradoxical Role of T-type Calcium Channels in Coronary Smooth Muscle
MI 2004 4: 16 10.1124/mi.4.1.16 [Summary] [Full Text] [PDF]  
Published February 1, 2004

Efrain C. Azmitia

Serotoninergic Chemoreceptive Neurons: A Search for a Shared Function
MI 2004 4: 18 10.1124/mi.4.1.18 [Summary] [Full Text] [PDF]  
Published February 1, 2004

Sergio Fazio and MacRae F. Linton

Apolipoprotein AI as Therapy for Atherosclerosis: Does the Future of Preventive Cardiology Include Weekly Injections of the HDL Protein?
MI 2003 3: 436 10.1124/mi.3.8.436 [Summary] [Full Text] [PDF]  
Published December 1, 2003

Rosanne M. Thomas and Daniel A. Peterson

A Neurogenic Theory of Depression Gains Momentum
MI 2003 3: 441 10.1124/mi.3.8.441 [Summary] [Full Text] [PDF]  
Published December 1, 2003

Hadi Al-Hasani, Matthias H. Tschöp, and Samuel W. Cushman

Two Birds with One Stone: Novel Glucokinase Activator Stimulates Glucose-Induced Pancreatic Insulin Secretion and Augments Hepatic Glucose Metabolism
MI 2003 3: 367 10.1124/mi.3.7.367 [Summary] [Full Text] [PDF]  
Published October 1, 2003

Mark E. Olah and Charles C. Caldwell

Adenosine Receptors and Mammalian Toll-Like Receptors: Synergism in Macrophages
MI 2003 3: 370 10.1124/mi.3.7.370 [Summary] [Full Text] [PDF]  
Published October 1, 2003

Zigang Dong and Ann M. Bode

Dialogue Between ERKs and JNKs: Friendly or Antagonistic?
MI 2003 3: 306 10.1124/mi.3.6.306 [Summary] [Full Text] [PDF]  
Published September 1, 2003

Marina E. Wolf

LTP May Trigger Addiction
MI 2003 3: 248 10.1124/mi.3.5.248 [Summary] [Full Text] [PDF]  
Published August 1, 2003

Mark J. Smyth and Michael H. Kershaw

Discovery of an Innate Cancer Resistance Gene?
MI 2003 3: 186 10.1124/mi.3.4.186 [Summary] [Full Text] [PDF]  
Published June 1, 2003

Kazuyoshi Yonezawa

Identification of TOR-interacting Proteins
MI 2003 3: 189 10.1124/mi.3.4.189 [Summary] [Full Text] [PDF]  
Published June 1, 2003

Harald Wajant

Targeting the FLICE Inhibitory Protein (FLIP) in Cancer Therapy
MI 2003 3: 124 10.1124/mi.3.3.124 [Summary] [Full Text] [PDF]  
Published May 1, 2003

Stéphanie Dutertre and Claude Prigent

Aurora-A Overexpression Leads to Override of the Microtubule-Kinetochore Attachment Checkpoint
MI 2003 3: 127 10.1124/mi.3.3.127 [Summary] [Full Text] [PDF]  
Published May 1, 2003