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Molecular Interventions 7:195-199, (2007)
© American Society for Pharmacology and Experimental Therapeutics
10.1124/mi.7.4.5
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Microsomal Prostaglandin E2 Synthase: A Safer Target than Cyclooxygenases?

Leo Timmers1, Gerard Pasterkamp1 and Dominique P.V. de Kleijn1,2

1 Laboratory of Experimental Cardiology, University Medical Center Utrecht, the Netherlands and
2 Interuniversity Cardiology Institute of the Netherlands

SUMMARY

Non-steroidal anti-inflammatory drugs (NSAIDs) are inhibitors of the cyclo-oxygenase (COX)-1 and -2 activities of prostaglandin G/H synthase-1 and -2, respectively. They have been extensively used in the treatment of prostaglandin E2–mediated chronic inflammatory diseases. Selective COX-2 inhibitors (coxibs), which were developed to provide an alternative with reduced gastrointestinal risk for the traditional NSAIDs, have been associated with an increased incidence of major adverse cardiovascular events. Could the targeting of microsomal prostaglandin E2 synthase (mPGES-1) lead to novel anti-inflammatory drugs with possibly reduced risks of gastrointestinal and cardiovascular side effects?






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