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Molecular Interventions 7:99-111, (2007)
© American Society for Pharmacology and Experimental Therapeutics
10.1124/mi.7.2.10
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REGULATION OF DRUG TRANSPORTERS: DURING INFECTION AND INFLAMMATION

Vanja Petrovic, Shirley Teng and Micheline Piquette-Miller

Department of Pharmaceutical Sciences, University of Toronto, Ontario, Canada


Formula

Inflammation-induced changes in the pharmacokinetics and dynamics of numerous drugs have been reported. Altered drug disposition during inflammatory disease has traditionally been ascribed primarily to changes in drug metabolism and protein binding. Emerging evidence within the last decade, however, has demonstrated that the inflammatory response affects the expression of several important drug transporters and these changes significantly impact the disposition and activity of drug substrates.




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Copyright © 2007 by the American Society for Pharmacology and Experimental Therapeutics.