HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Zhou, Q.-Y. Search for Related Content PubMed PubMed Citation Articles by Zhou, Q.-Y.

The Prokineticins: A NOVEL PAIR OF REGULATORY PEPTIDES

Department of Pharmacology, University of California, Irvine, California 92697

Secreted peptides play broad regulatory roles in brain function and elsewhere in the body. Prokineticins are a pair of newly identifi ed regulatory peptides that signal through two highly homologous G protein–coupled receptors. Prokineticins possess a unique structural motif of fi ve disulfi de bonds and a completely conserved N-terminal hexapeptide sequence that is essential to biological activity. Diverse biological functions, including roles in development and cell differentiation, have been assigned to the prokineticins. A network of genes, subject to various transcriptional factors, may functionally converge on the prokineticins as regulatory targets.