MI Sign Up for eTOC Alerts
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Molecular Interventions 6:257-265, (2006)
© American Society for Pharmacology and Experimental Therapeutics
10.1124/mi.6.5.7
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Vortherms, T. A.
Right arrow Articles by Roth, B. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Vortherms, T. A.
Right arrow Articles by Roth, B. L.
Review

Salvinorin A

From Natural Product to Human Therapeutics

Timothy A. Vortherms1 and Bryan L. Roth1,2

1 Department of Pharmacology, School of Medicine and
2 Division of Medicinal Chemistry and Natural Products, School of Pharmacy, University of North Carolina, and National Institute of Mental Health Psychoactive Drug Screening Program, Chapel Hill, NC 27599


Formula

The hallucinogenic plant Salvia divinorum (i.e., "magic mint") is a member of the Sage family that has been used for divination and shamanism by the Mazatecs. Over the past decade or so, S. divinorum has been increasingly used recreationally. The neoclerodane diterpene salvinorin A is the active component of S. divinorum, and recently, the {kappa} opioid receptor (KOR) has been identified, in vitro and in vivo, as its molecular target. The discovery of KOR as the molecular target of salvinorin A has opened up many opportunities for drug discovery and drug development for a number of psychiatric and non-psychiatric disorders.




This article has been cited by other articles:


Home page
 J. Pharmacol. Exp. Ther.Home page
C. Beguin, D. N. Potter, J. A. DiNieri, T. A. Munro, M. R. Richards, T. A. Paine, L. Berry, Z. Zhao, B. L. Roth, W. Xu, et al.
N-Methylacetamide Analog of Salvinorin A: A Highly Potent and Selective {kappa}-Opioid Receptor Agonist with Oral Efficacy
J. Pharmacol. Exp. Ther., January 1, 2008; 324(1): 188 - 195.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. R. Bruchas, B. B. Land, M. Aita, M. Xu, S. K. Barot, S. Li, and C. Chavkin
Stress-Induced p38 Mitogen-Activated Protein Kinase Activation Mediates {kappa}-Opioid-Dependent Dysphoria
J. Neurosci., October 24, 2007; 27(43): 11614 - 11623.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ASPET Journals Pharmacological Reviews Drug Metabolism and Disposition
Molecular Interventions Molecular Pharmacology J Pharmacology and Exp Therapeutics
Copyright © 2006 by the American Society for Pharmacology and Experimental Therapeutics.